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Analyzing Large Protein Complexes by Structural Mass Spectrometry
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通过在高气压下发生碰撞诱导的解离来阐明蛋白质复合物的结构

Fanny C Liu1, Tyler C Cropley1, Christian Bleiholder1,2

  • 1Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States.

Journal of the American Society for Mass Spectrometry
|September 20, 2023
PubMed
概括

碰撞诱导解离 (CID) 在并联捕获离子移动性谱法 (Tandem-TIMS) 中的高压下有效地将蛋白质复合体分解为子单元. 这种方法保留了原生结构特征,为蛋白质复杂结构提供了新的见解.

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