在患有经典性和变异性毛状细胞白血病的患者中,COVID-19
Robert J Kreitman1, Theresa Yu2, Lacey James1
1Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD.
患有毛细胞白血病 (HCL) 和其变体 (HCLv) 的患者的COVID-19感染率很高,但大多数人康复良好. 较低的B细胞计数与较差的抗体反应和较长时间从COVID-19中恢复相关.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 毛细胞白血病 (HCL) 和它的变体 (HCLv) 是B细胞恶性瘤,已知会损害幽默免疫力.
- 患有HCL/HCLv的患者可能面临更高的风险,患有COVID-19等感染的严重结果.
研究的目的:
- 为了对大量的HCL/HCLV患者进行前性监测,以确定COVID-19感染和结果.
- 调查免疫标记物,HCL/HCLv状态和COVID-19结果之间的关系.
主要方法:
- 使用症状评估,抗体测试和PCR/抗原测试对503名HCL/HCLV患者进行COVID-19的前性监测.
- 分析COVID-19感染率,临床结果以及与B细胞计数和最近的HCL/HCLv治疗的相关性.
主要成果:
- 50%的HCL/HCLv患者感染了COVID-19,大多数通过PCR或抗原测试检测阳性.
- 尽管免疫抑制和最近的治疗,几乎所有的患者恢复无事故,低死亡率 (约. 1%).一个百分点).
- 较低的正常B细胞计数,通常是由于HCL或治疗,与降低的尖端抗体水平和更长的COVID-19恢复时间有关.
结论:
- 在HCL/HCLv患者中,COVID-19的结局通常是有利的,死亡率低,并有不常见的后果.
- 正常B细胞枯竭的程度显著影响了这些患者对COVID-19的免疫反应和恢复时间.
更多相关视频
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Mechanisms of Retrovirus-induced Cancers
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
