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血清甲酸盐暴露与中国人口发生2型糖尿病风险的关联:一项嵌套病例对照研究

Shiyang Zhang¹, Xu Cheng¹, Chengyong Jia¹

¹Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan 430030, Hubei, China.

Ecotoxicology and environmental safety

|September 20, 2023

概括

在一般人群中,甲酸盐暴露与2型糖尿病无关. 然而,当前接触某些酸盐的饮酒者,如DnBP,患2型糖尿病的风险增加.

科学领域:

环境健康环境健康
流行病学流行病学
内分泌学在内分泌学.

背景情况:

酸盐 (PAE) 是常见的环境污染物.
将PAE暴露与发生的2型糖尿病 (T2DM) 风险联系在一起的前性证据有限.
了解这些关联对于公共卫生至关重要.

研究的目的:

调查血清甲酸盐水平与T2DM发生风险之间的关联.
为了评估PAE作为单个药物和混合物.
为了确定潜在的敏感子群体关于PAE对T2DM的影响.

主要方法:

在东-通吉队伍内进行了嵌套病例控制研究.
在基线血清样本中量化6种PAE.
条件逻辑回归,贝叶斯核机器回归和基于量子的g计算的应用.

主要成果:

在一般人群中,整体PAE暴露和事件T2DM之间没有显著的关联.
在目前饮酒者中观察到的T2DM风险增加,他们的血清中甲酸丁 (DnBP),甲酸丁 (ΣDBP) 和低分子量甲酸 (ΣLMW) 含量较高.
特定酸盐 (DiBP, DnBP, BBP, ΣDBP, ΣLMW) 与饮酒状态在T2DM风险上的显著相互作用.

结论:

单独暴露于甲酸盐似乎不会增加一般人群T2DM风险.
当前的酒精消费可能会改变某些酸盐与T2DM风险之间的关联.
对暴露于特定甲酸盐的饮酒者进行有针对性的干预可能是有必要的.

关键词:

目前的饮酒者饮酒者嵌套病例控制研究研究.酸盐 (PAE) 是一种酸盐.二型糖尿病 (T2DM) 是一种糖尿病.

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