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巨相关的元炎症标志物与儿科肥胖的代谢功能障碍有关

Julia Lischka¹, Andrea Schanzer², Charlotte de Gier²

¹Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria; Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria; Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria.

|September 20, 2023

概括

儿童肥胖与脂肪组织巨细胞炎症有关. 像IL-1RA,sCD163和OPN这样的高标志物与代谢功能障碍有关,包括脂肪肝疾病和儿童胰岛素抵抗.

科学领域:

免疫学免疫学免疫学
儿科内分泌学儿科内分泌学
代谢性疾病研究研究

背景情况:

由脂肪组织巨细胞 (ATM) 驱动的代谢炎症是肥胖的核心原因,并导致心脏代谢疾病.
ATM表达支持和抗炎标志物,包括IL-1受体对抗剂 (IL-1RA),CD163和骨质素 (OPN).

研究的目的:

调查ATM相关标志物与儿科肥胖的代谢并发症之间的关联.
为了确定IL-1RA,sCD163和OPN的血水平是否与儿童的代谢功能障碍相关.

主要方法:

对患有肥胖症的儿科队列 (n=108) 的分析.
使用ELISA测量血IL-1RA,可溶性CD163 (sCD163) 和OPN.
临床表征包括常规血液参数,口服葡萄糖耐受性测试和肝脏MRI.

主要成果:

患有代谢功能障碍相关的脂肪肝疾病 (MAFLD) 和代谢综合征的儿童显示血IL-1RA,sCD163和OPN显著增加.
IL-1RA和sCD163水平与肝病和亡标志物 (ALT,CK-18) 相关联.
IL-1RA与胰岛素抵抗相关,在患有葡萄糖代谢障碍的儿童中观察到更高的sCD163水平.

结论:

脂肪组织巨细胞相关炎症标志物升高与MAFLD和其他儿童肥胖的代谢障碍有关.
这些发现突显了元炎症在肥胖儿童代谢并发症的发展中的作用.

关键词:

脂肪组织的巨细胞互乐金-1受体对抗剂互乐金-1受体对抗剂与代谢功能障碍相关的脂肪肝疾病.骨质疏松素是一种骨质疏松素.可溶性CD163是一种可溶性CD163

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Obesity

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