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未知发作的中风的特征和结果:日本中风数据库

Shinichi Wada¹, Sohei Yoshimura², Kazunori Toyoda²

¹Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.

Journal of the neurological sciences

|September 20, 2023

概括

未知发作的中风 (UOS) 与更糟糕的结果有关,特别是在男性中. 然而,女性和接受再注血治疗的患者的结果有所改善,扩大了治疗的可能性.

科学领域:

神经学神经学
心血管医学心血管医学
公共卫生公共卫生

背景情况:

未知发病性中风 (UOS) 在确定适用于时间敏感的再注血疗法的资格方面存在挑战.
扩大UOS的治疗窗口对于改善临床结果至关重要.

研究的目的:

描述与UOS相关的患者人口统计和临床结果.
为了比较UOS患者与已知发病性中风 (KOS) 患者.

主要方法:

分析了全国范围的潜在注册表 (日本中风数据库) 的急性缺血性中风 (AIS) 患者在最后一个已知的时间 (2017年1月至2020年12月) 的24小时内入院.
共同初级结局包括入院国家中风研究所 (NIHSS) 评分和出院时的不利结局 (修改的兰金尺度[mRS]分数为3-6).
使用多变量分析来确定与UOS相关的因素,并比较UOS和KOS组之间的结果.

主要成果:

该研究包括26,976名AIS患者;5,783人患有UOS. 与KOS患者相比,患有UOS的患者年龄较大,NIHSS得分较高,结果不利.
与UOS相关的因素包括年龄较大,女性性别,高预发性mRS,心房动和充血性心力衰竭.
虽然UOS与较差的结果相关 (调整后几率比1.27),但这种关联在女性和接受再注射治疗的患者中减弱.

结论:

不知发病的中风与不良的临床结果有关.
在女性患者和接受再注射治疗的患者中,UOS对结果的负面影响较小.
这些发现表明再注射治疗的潜在益处,并突出了中风结果的性别特异性差异.

关键词:

日本日本日本日本日本.重灌疗法是一种重灌疗法.性差异性差异性差异性差异性差异性差异性差创伤注册表中的创伤记录.发病时间不明的中风中风.

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