抗微生物与罗内拉尔结合,有效地杀死多药耐药细菌
Zhanyi Yang1, Shiqi He1, Yingxin Wei1
1College of animal science and technology, Northeast Agricultural University, Harbin 150030, P. R. China.
Phytomedicine : international journal of phytotherapy and phytopharmacology
|September 20, 2023
概括
ZY4R和罗内拉尔的组合显示了针对病原体的广泛抗微生物协同作用. 这种组合增强了疗效和生物安全性,为抗生素耐药性提供了有前途的策略.
科学领域:
- 发现抗微生物药物发现.
- 类抗生素的协同作用.
- 细菌病原体的发生.
背景情况:
- 抗微生物 (AMP) 显示出对抗抗生素耐药性的潜力,但具有成本和有效性等局限性.
- 与罗内拉尔等辅助剂的联合治疗可能会提高AMP的有效性.
- 对于ZY4R/citronellal对细菌的协同抗微生物作用和机制尚不清楚.
研究的目的:
- 为了研究ZY4R/citronellal组合的协同抗微生物疗效.
- 评估这种联合治疗的生物安全性和作用机制.
- 探索其作为传统抗生素替代品的潜力.
主要方法:
- 棋盘测定和杀时曲线评估了协同作用的抗微生物效应.
- 细胞毒性测定和体内动物模型评估了生物安全性.
- 基于细胞的测定和转录组分析阐明了协同机制.
主要成果:
- 在ZY4R/citronellal组合证明了对20种病原体的协同抗微生物活性 (FICI 0.047-0.313).
- 该组合增强了有效性,而不影响细胞选择性,改善了生物安全性并减少了所需的药物剂量.
- 在体内研究表明,在接受该组合治疗的小鼠中,细菌负荷和器官损伤减少.
- 机理学研究揭示了对细菌膜,能量代谢和外聚糖类生产的双重作用.
结论:
- ZY4R/罗内拉尔组合表现出广泛的协同作用,低抗性潜力和高生物安全性.
- 协同机制涉及准细菌能量代谢和膜完整性.
- 这种组合是对抗抗生素耐药性危机的有希望的治疗策略.
相关概念视频
01:27Combined Effects of Drugs: Synergism
4.0K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.0K
01:23Antimicrobial Proteins
1.0K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.0K
01:28Antimicrobial Effectiveness
43
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
43
01:28Biological Methods for Microbial Control
61
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
61
01:28Gene Regulation in Microbial Communities: Quorum Sensing
38
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
38
01:27Chemical Agents for Microbial Control
54
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
54