认知障碍与新发性中风有关:来自全国前性队列研究的证据
Tian Qiao1, Hongzhuan Lu1, Xianghua Wang1
1Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Cerebrovascular diseases (Basel, Switzerland)
|September 20, 2023
概括
认知障碍增加了45岁及以上的中国成年人新发性中风的风险. 这项前性研究发现,认知障碍患者中风的几率高出22%.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 老年学是指老年学的学科.
背景情况:
- 脑卒中显著影响认知功能,但相反的关联,即认知障碍是否预测脑卒中,尚不清楚.
- 现有的研究缺乏关于认知衰退与未来中风风险之间的联系的确证据.
研究的目的:
- 研究认知障碍与新发性中风的发生率之间的关联.
- 确定先前存在的认知缺陷是否是首次非致命性中风的危险因素.
主要方法:
- 利用来自中国健康与退休长度研究 (20112018) 的11961名中国成年人 (≥45岁) 的数据.
- 根据基线得分,参与者被分为认知障碍和正常认知组.
- 后勤回归分析评估了基线认知状态和新发性中风之间的关系,并对混因素进行了调整.
主要成果:
- 在长达6.96年的随访期间,875名参与者经历了新发性中风.
- 认知障碍的个体患上新发性中风的几率比认知正常的个体高22% (OR 1.22;95% CI 1.011.48),经过对混因素的调整后,与认知正常的个体相比.
- 在考虑到人口,医疗,物理和实验室因素后,这种关联仍然很重要.
结论:
- 认知障碍是中年和老年中国人中新发性中风的重要危险因素.
- 这些发现表明认知健康和脑血管疾病风险之间存在潜在联系.
- 需要进一步的研究来确定因果关系并探索潜在的机制.
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