双极性障碍与自杀企图中的海马体动态功能连接,HPA轴活动和人格特征
Shuming Zhong1, Pan Chen2, Shunkai Lai3
1Department of Psychiatry, First Affiliated Hospital, Jinan University, Guangzhou, China, shuming19882006@126.com.
Neuroendocrinology
|September 20, 2023
概括
自杀性双极性障碍 (BD) 患者表现出大脑连接的改变和下丘脑-垂体-上腺 (HPA) 轴活动的减少,影响诸如抑郁症之类的性格特征.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 双极性障碍 (BD) 中的自杀是复杂的,涉及神经内分泌和心理因素.
- 以前的研究表明,自杀性BD患者的动态功能连接 (dFC) 和下丘脑-垂体-上腺 (HPA) 轴活动受损.
- 与自杀相关的个性特征可能与这些神经生物学变化有关.
研究的目的:
- 在自杀性BD患者中调查海马体亚区域和HPA轴活性中的动态功能连接 (dFC) 变异性.
- 探索这些神经生物学标志物与与自杀有关的个性特征之间的关联.
- 为了澄清双相情感障碍中自杀背后的机制.
主要方法:
- 休息状态fMRI数据分析了79名BD患者的dFC变异性 (39名自杀尝试[SA],40名没有SA) 和35名健康对照 (HCs).
- 通过血ACTH和皮质醇水平评估HPA轴活性.
- 使用明尼苏达州多相人格清单-2 (MMPI-2) 进行人格评估.
主要成果:
- 与非SA BD患者和HCs相比,SA BD患者在右尾部海马和左上旋 (STG) 之间表现出增加的dFC可变性.
- 与SA相关的BD显示了较低的ACTH水平,与海马-STGdFC变异性增加正相关.
- 患有SA的BD在MMPI-2上对缺陷体质症,抑郁症和精神分裂症的得分更高.
结论:
- 自杀性BD的特点是增加海马-时间皮层的dFC变异性.
- 在自杀性BD患者中观察到减少HPA轴过度活跃.
- 这些神经生物学变化可能会影响自杀性BD个体的个性特征.
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