嗅觉球体活动塑造了内-海马合的发展以及相关的认知能力
Yu-Nan Chen1, Johanna K Kostka1, Sebastian H Bitzenhofer1
1Institute of Developmental Neurophysiology, Center of Molecular Neurobiology, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Current biology : CB
|September 20, 2023
概括
新生儿嗅球活动对于发展大脑电路至关重要. 在小鼠中,暂时静止嗅觉球的输出,导致长期认知功能和大脑发育受损.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 认知神经科学 认知神经科学
背景情况:
- 嗅觉和认知之间的联系在成年人中是已知的,但其发展轨迹尚不清楚.
- 早期的嗅球 (OB) 活动会影响下游的大脑区域,如侧内皮质 (LEC) 和海马体 (HP).
研究的目的:
- 调查早期嗅觉球泡活动对内海马回路发育和认知功能的长期影响.
- 为了确定暂时的新生儿OB沉默是否会影响后期的认知能力.
主要方法:
- 在出生后8-10天的小鼠的OB中,化学基因沉默的 mitra/tufted 细胞突触输出在出生后8-10天.
- 评估了振荡合,刺激反应,神经元形态和行为测试中的表现.
主要成果:
- 暂时的OB静音导致振荡合减少,并在开发LEC-HP电路时对刺激反应较弱.
- 观察到LEC金字塔神经元的树突化.
- 在依赖于内-海马回路的行为测试中,小鼠的表现受损.
结论:
- 新生儿嗅觉球的活性对于内 - 海马回路的正常功能发育和成熟至关重要.
- 早期的嗅觉处理在认知能力的长期发展中起着至关重要的作用.
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