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通过移植化和交叉链接修饰的包西兰衍生物的合成和抗瘤活性

Bin Zhao¹, Heping Li¹, Kexin Tian¹

¹College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China.

International journal of biological macromolecules

|September 20, 2023

概括

研究人员修改了包西兰 (BX) 成一种新型衍生物,CA-BX-g-BMA,增强了其结构和热稳定性. 这种衍生物显示出对乳腺癌细胞具有有前途的抗瘤活性,对正常细胞的毒性最小.

科学领域:

生物质价值化和可持续材料科学.
聚合物化学和材料改造.
新生物材料的生物医学应用.

背景情况:

可持续发展需要将可再生生物质转化为高价值的功能材料.
包西兰 (BX) 是一种可再生的多糖,是先进材料合成的潜在原料.
自然聚合物的化学修饰可以产生具有增强性质和新功能的材料.

研究的目的:

合成了一种具有改进性质的酸移植的新型巴加斯西兰衍生物 (CA-BX-g-BMA).
描述BX在经过修改后的结构,热和形态变化.
评估合成衍生物的生物活性,包括抗瘤潜力和结合瘤蛋白的亲和力.

主要方法:

包西兰 (BX) 与基甲酸盐 (BMA) 的移植共聚合,形成BX-g-BMA.
在AmimCl离子液中用酸 (CA) 催化乙化BX-g-BMA,从而产生CA-BX-g-BMA.
使用DFT,MEP,分子对接和MTT试验等技术进行表征,以评估生物活性.

主要成果:

合成导致了BX形态的显著变化,改善了热稳定性和增强了结晶性.
CA-BX-g-BMA对6RCF瘤蛋白 (-32.26 kJ/mol) 和多个活性位点表现出强烈的结合亲和力.
在体外研究表明,CA-BX-g-BMA抑制乳腺癌细胞 (MDA-MB-231) 的32.16%±4.89%没有对正常细胞的毒性,比BX提高了11倍.

结论:

CA-BX-g-BMA是一种新的,高价值的功能性材料,来自可再生的包西兰.
修改后的西兰衍生物显示出生物医学应用的巨大潜力,特别是作为抗癌剂.
进一步探索BX衍生物对于推动可持续材料和医学领域的多学科应用至关重要.

关键词:

抗癌活性抗癌活性包是基于西兰的功能材料.生物对接生物对接在 CA-BX-g-BMA 衍生函数中.标志性描述标志性描述综合合成综合合成

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