优化基于外体的无细胞策略,以增强组织再生中的内源细胞功能
Siyan Deng1, Hongfu Cao1, Xiaolin Cui2
1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610065, China; College of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Acta biomaterialia
|September 20, 2023
概括
外体对组织再生有前途,但需要仔细选择和工程. 内容加载和生物材料结合等策略增强了它们的治疗潜力,用于无细胞疗法.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 细胞生物学 细胞生物学
背景情况:
- 外体,纳米级的细胞外囊泡,是通过它们的RNA和蛋白质载荷进行细胞间通信的关键媒介.
- 外体体对在组织再生中进行无细胞治疗具有显著的前景.
- 自然外体的局限性包括低目标特异性,非组织特异性向和短暂的体内保留.
研究的目的:
- 审查来自不同细胞源的外体,用于组织再生.
- 突出工程策略,以克服自然外体在治疗中的局限性.
- 讨论加强基于外体细胞的无细胞疗法的协同方法.
主要方法:
- 对外体源和组织再生中的功能进行文献综述.
- 对外体细胞修饰工程策略的分析.
- 讨论用于控制释放和保留的生物材料的结合.
主要成果:
- 鉴定特定的外体功能,用于各种细胞来源的组织修复.
- 对将治疗内容装入外体体的方法的描述.
- 解释组织特异向和延长体内保留的技术.
结论:
- 基于外体细胞的无细胞疗法是一个快速发展的领域,具有显著的治疗潜力.
- 工程外体对优化它们的有效性和克服当前的局限性至关重要.
- 对外体属性的协同增强对广泛的组织再生应用有希望.
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