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热/超声触发释放从微泡中装载Ganoderma applanatum多糖体的脂质体,以增强瘤切除

Jiani Yuan¹, Lei Ding¹, Lu Han²

¹Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Journal of controlled release : official journal of the Controlled Release Society

|September 20, 2023

概括

这项研究引入了Ganoderma applanatum多糖体 (GAP) 脂质体-微泡复合体 (GLMCs),用于增强肝脏瘤治疗. 超声波向的微泡破坏与高温症通过抑制瘤相关的巨细胞有效抑制瘤生长.

科学领域:

在瘤学瘤学.
生物医学工程生物医学工程
免疫学免疫学免疫学

背景情况:

对于肝脏瘤的热除有不完整治疗和残留疾病的风险.
与瘤相关的巨细胞 (TAMs) 可以阻碍有效的癌症治疗.

研究的目的:

开发一种使用Ganoderma applanatum多糖化物 (GAP) 脂质体-微泡复合物 (GLMCs) 进行热除的增强策略.
为了研究超声向微泡破坏 (UTMD) 和亚致命性高温症 (SH) 在抑制肝脏瘤中的有效性.

主要方法:

通过将GAP脂质体与微泡相结合来制备GLMC.
在体外研究中评估了UTMD对M2类巨细胞及其分泌物的影响.
在体内研究评估了用UTMD和SH字段对子VX2肝瘤的GLMC治疗.

主要成果:

UTMD促进了细胞吸收和M2类巨细胞亡,减少了阿尔金酶-1 (Arg-1) 和转化生长因子-β (TGF-β) 的分泌.
在体内,通过UTMD和SH进行的GLMC治疗显著限制了子VX2肝瘤体积.
观察到TAM标记物 (CD68,CD163),增殖 (Ki67) 和血管生成 (CD31) 因素的表达减少.

结论:

热/美国触发药物释放从GLMCs有效抑制肝脏瘤的生长在一个亚致命的高热场.
该策略通过抑制TAM来起作用,提供了一种潜在的方法来提高热除效率.

关键词:

这种植物是 Ganoderma applanatum 的多糖体.热量过高的情况.脂质细胞体中的脂肪体.微气泡是一种微气泡.与瘤相关的巨细胞.超声波超声波是指超声波的使用.

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