在乳牛小牛的肠道屏障,炎症信号和微生物群体中,与热应激相关的变化
Z Yu1, J M Cantet1, H A Paz2
1Department of Animal Science, University of Tennessee Institute of Agriculture, Knoxville, TN 37996.
Journal of dairy science
|September 20, 2023
概括
热应激会损害正在成长的小牛的肠道屏障功能,特别是在阴. 肠道微生物群的转变可能有助于保持结肠健康,这表明针对热应激的向治疗是至关重要的.
科学领域:
- 动物科学动物科学
- 生理学 生理学 生理学
- 微生物学 微生物学
背景情况:
- 热应激会对动物健康产生负面影响,导致肠道功能障碍,炎症和失生症.
- 了解特定组织的变化对于开发针对小牛热应激疾病的干预措施至关重要.
研究的目的:
- 研究热应激对荷尔斯坦牛犊肠道屏障成分,炎症标志物和肠道微生物群的影响.
- 为了识别阴,大肠和结肠的切口特异性改变.
主要方法:
- 荷尔斯泰因公牛犊在7天内受到热中性 (TNR) 或热应激 (HS) 条件.
- 肠道组织 (肠膜,大肠,结肠) 分析了基因/蛋白质表达和细胞因子度.
- 评估了肠道和血中细胞因子中的细菌群落.
主要成果:
- 热应激显著降低了头骨TJP1mRNA表达和热冲击转录因子-1蛋白质水平.
- 在热应激下,Jejunal IL-1α降低,而IL-36受体对手在热应激下增加.
- 大肠微生物群在受热应激的小牛中显示出酸盐产生细菌 (例如,Butyrivibrio_3) 的增加.
结论:
- 热应激会损害膜屏障的完整性,但可能会促进结肠中有益的微生物变化.
- 调节肠道平衡是减轻小牛热应激效应的关键目标.
- 这项研究强调了热应激对小牛肠道的部分特异性影响.
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