在定制的基于铁的合介质中,化发生的概率,用于跨磁共振引导的聚焦超声波程序
Connor Edsall1, Austin Fergusson2, Richey M Davis3
1Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
聚甲酸涂层的氧化铁纳米颗粒 (PMAA-FeOX) 提高了跨MR指导聚焦超声波 (tMRgFUS) 的MRI兼容性,而不会增加洞穴的风险. 这种新的基于铁的合介质 (IBCM) 保持了tMRgFUS程序的安全化值.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 声学 声学 在声学方面
背景情况:
- 跨的MR指导聚焦超声波 (tMRgFUS) 需要一个脱气的水合浴室,以达到声传导.
- 标准的水合浴会在tMRgFUS过程中干扰实时MRI.
- 以前的铁基合介质 (IBCM) 减少了MRI信号,但降低了化值.
研究的目的:
- 评估新型聚甲酸涂层氧化铁纳米颗粒 (PMAA-FeOX) 作为IBCM对化值的影响.
- 确定PMAA-FeOX是否可以在不影响tMRgFUS安全的情况下减轻MRI干扰.
主要方法:
- 在脱气水中研究了PMAA-FeOX纳米颗粒的度增加.
- 通过被动化检测和高速光学成像来评估化值.
- 测试了代表tMRgFUS模式的低功率周期和高功率周期脉冲参数.
主要成果:
- 对于PMAA-FeOX IBCM的平均空洞化值与脱气水控制器无法区分.
- 高功率周期的值在6-8MPa之间,非常低功率周期脉冲的值在25.5-26.5MPa之间.
- 在使用PMAA-FeOX IBCM时没有观察到焦点前化风险的增加.
结论:
- PMAA-FeOX纳米粒子是减少tMRgFUS合浴中的MRI干扰的可行解决方案.
- 这种IBCM保持了安全的化压力极限,这对于tMRgFUS应用至关重要.
- 这项研究证实了PMAA-FeOX在增强的tMRgFUS程序中的安全性和有效性.
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