在过早的卵巢衰竭中发生的美图和撕裂功能改变
F Sumer1, S Subasi2, B Gurlek3
1Recep Tayyip Erdogan University, Faculty of Medicine, Deparment of Ophthalmology, Rize, Turkey.
Journal francais d'ophtalmologie
|September 20, 2023
概括
过早的卵巢衰竭 (POF) 与增加干眼症状和眼睛表面损伤有关. POF患者的荷尔蒙变化可能会影响膜组成和梅博米腺结构,导致早期出现的眼睛疾病.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 生殖科学 生殖科学
背景情况:
- 过早的卵巢衰竭 (POF) 影响40岁之前的卵巢功能.
- POF可能与各种因素有关,包括遗传,自身免疫和荷尔蒙失衡.
- 干眼症状和早期更年期发现可能发生在POF患者中.
研究的目的:
- 为了比较POF患者与健康对照者的眼膜变化和梅博米腺状况.
- 为了调查诊断为POF的妇女的眼睛表面健康状况.
主要方法:
- 评估了90名POF患者和60名对照人群.
- 评估的眼表面疾病指数 (OSDI),角膜/结膜干扰 (牛津得分),膜测试 (Schirmer,非侵入性撕裂破裂时间 - NIBUT).
- 分析了使用非接触式meibography的meibomian腺脱落,扭曲和缩短.
主要成果:
- POF患者的OSDI分数和牛津分数显著更高.
- 在POF患者中,NIBUT显著降低.
- 梅博米腺在POF患者中显示出显著的扭曲,尽管学和缩短是相似的.
结论:
- 眼睛表面损伤和干眼在POF患者中更为普遍.
- 在POF中的荷尔蒙缺乏可能会破坏眼膜,眼睛表面平衡,以及梅博米腺结构.
- 早期发生的梅博米腺扭曲是POF中的荷尔蒙变化的潜在后果.
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