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在智力障碍青少年中,矿物质元素和与脂肪相关的后果
Ahmad H Alghadir1, Sami A Gabr1, Amir Iqbal2
1Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh, 11433, Saudi Arabia.
BMC molecular and cell biology
|September 20, 2023
概括
智力障碍与改变的矿物元素,阿迪波金和氧化应激有关. 这些因素可能有助于诊断青少年中度智力障碍 (MID).
科学领域:
- 生物化学 生物化学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 智力障碍患者由于合作和沟通的局限性,往往会面临独特的医疗保健挑战.
- 专业的注意力对于管理这个群体的生物后果至关重要.
研究的目的:
- 评估智力障碍青少年的矿物质元素水平.
- 评估矿物质元素,氧化应激标记物和脂肪性标记物 (莱普丁,阿迪波内克丁,L/A比率) 之间的相关性.
主要方法:
- 一项前性观察性研究,涉及300名青少年 (年龄12-18岁),分为健康对照组 (IQ 90-114) 和中度智力障碍 (MID) 组 (IQ 35-49).
- 通过ICP-MS,色度测量和免疫测试技术评估脂肪标志物 (BMI,WHR,WHtR),体力活动,脂肪基因 (莱普,阿迪波涅丁),氧化应激标志物 (MDA,TAC) 和血矿物元素.
主要成果:
- 与对照人群相比,患有MID的青少年表现出明显更高的肥胖指标 (BMI,WHR,WHtR) 和较低的体力活动.
- 在MID组中观察到高水平的瘦素,氨酸,L/A比率和氧化应激标志物 (MDA,TAC).
- 在MID患者中发现了矿物元素水平的显著变化,Fe,Mn,Zn,Hg,Pb,Ca,Cr,Mg,Ni的增加和Al,Na,K,Cu,Zn/Cu比率的降低.
- 矿物元素的变化与脂肪标志物,氧化应激和智力障碍得分密切相关.
结论:
- 中度智力障碍 (MID) 与异常的矿物元素和阿迪波金水平有关,同时增加了细胞氧化应激.
- 血矿物质元素和阿迪波金 (adipokine) 分析可以作为MID的潜在诊断参数.
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