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对偏头痛及其亚型的遗传责任对乳腺癌的影响:孟德尔的随机化研究

Tian Fang¹, Zhihao Zhang², Huijie Zhou¹

¹Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, Sichuan, 610041, China.

|September 20, 2023

概括

偏头痛是整体和雌激素受体阳性乳腺癌的危险因素. 没有光环的偏头痛也可能增加雌激素受体阴性乳腺癌的风险,需要进一步调查.

科学领域:

遗传学遗传学是一个
流行病学流行病学
在瘤学瘤学.

背景情况:

关于偏头痛和乳腺癌风险之间的关联,存在相互矛盾的证据.
门德尔的随机化 (MR) 分析被用来研究这种关系.

研究的目的:

用遗传数据评估偏头痛与患乳腺癌的风险之间的关联.
为了区分各种乳腺癌亚型的风险关联.

主要方法:

利用了针对偏头痛的全基因组关联研究 (GWAS) 的遗传仪器.
采用逆变量加权 (IVW) 分析作为主要方法.
补充了加权中位数,MR-Egger,MR-PRESSO和MR-RAPS灵敏度分析.

主要成果:

任何偏头痛 (AM) 都与整体乳腺癌 (OR=1.072) 和雌激素受体阳性 (ER+) 乳腺癌 (OR=1.066) 的风险增加有关.
没有光环的偏头痛 (MO) 与雌激素受体阴性 (ER-) 乳腺癌的风险增加有显著关联 (OR=1.089).
此外,MO与整体乳腺癌风险有明显的关联.

结论:

患有任何偏头痛 (AM) 的女性患整体和ER+乳腺癌的风险更高.
没有光环 (MO) 的偏头痛与整体和ER-乳腺癌的风险增加有联系.

关键词:

任何偏头痛.乳腺癌是什么? 乳腺癌是什么?门德尔的随机化.偏头痛带有光环的偏头痛没有光环的偏头痛

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