与年龄有关的听力损失及其潜在的候选药物:系统性审查
Shiyu Hu1, Qingru Sun1, Fei Xu2
1School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, People's Republic of China.
Chinese medicine
|September 20, 2023
概括
与年龄相关的听力损失 (ARHL) 缺乏有效的治疗方法,但对其病理和风险因素的研究,包括传统中医 (TCM),提供了新的治疗途径. 草药及其化合物显示出通过抗氧化和抗炎作用保护听力.
科学领域:
- 老年学是指老年学的学科.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 与年龄相关的听力损失 (ARHL) 对老年人群产生重大影响,但缺乏有效的治疗方法.
- 目前对ARHL的研究受到全面临床试验缺乏的阻碍.
研究的目的:
- 系统地审查和分析有关ARHL病理,风险因素和治疗的最新数据.
- 评估传统中医 (TCM) 作为ARHL候选药物的潜在来源.
- 确定ARHL预防和治疗的新方法.
主要方法:
- 在2023年1月之前对数据库 (PubMed,WOS,CNKI,Wanfang) 进行全面的文献搜索.
- 提取和合成有关ARHL病理,病因,机制和治疗方法的数据.
- 专注于识别潜在的候选药物,包括来自TCM的药物.
主要成果:
- ARHL病因与遗传和环境因素有关,主要病理包括氧化损伤,线粒体功能障碍和炎症.
- 传统中医药 (TCM) 识别出来自,肺和肝 meridians 的草药具有保护听力特性.
- 草药中的活性化合物,如Polygonum multiflorum,Panax人参和Pueraria lobata,表现出抗氧化,神经保护和抗炎作用.
结论:
- 多种治疗策略,包括抗氧化剂和抗炎剂,显示出保护听力的潜力.
- 草药是对抗ARHL的新药候选药物的重要来源.
- 对TCM的进一步研究可能会为与年龄相关的听力损失提供有效的治疗方法.
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