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功能与循环中的三甲基胺N-氧化物之间存在因果关系和可修改关系的证据
Petros Andrikopoulos1,2, Judith Aron-Wisnewsky3,4, Rima Chakaroun5,6
1Section of Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. p.andrikopoulos04@imperial.ac.uk.
Nature communications
|September 20, 2023
概括
与心脏风险相关的三甲基胺N氧化物 (TMAO) 主要由功能调节,而不仅仅是饮食或肠道微生物. 这一发现表明,针对脏健康的潜在干预措施可以降低TMAO水平.
科学领域:
- 心血管科学 心血管科学
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 三甲基胺N氧化物 (TMAO) 是一种与心血管疾病 (CVD) 风险增加相关的代谢物.
- 流通中的TMAO水平的精确监管机制仍然不完全理解.
- 了解TMAO监管对于减轻与其相关的健康风险至关重要.
研究的目的:
- 在欧洲成年人队列中确定循环三甲基胺N氧化物 (TMAO) 水平的关键预测因素.
- 调查TMAO与功能之间的因果关系.
- 探索潜在的临床干预措施来管理与TMAO相关的心血管风险.
主要方法:
- 应用可解释的机器学习,单变量,多变量和调解分析.
- 分析了1,741名成年欧洲人的禁食血TMAO度和各种表型 (MetaCardis研究).
- 利用临床前模型验证TMAO对功能和痕的影响.
主要成果:
- 功能成为循环TMAO的主要预测因素,其次是年龄.
- 微生物群组成和饮食因素在TMAO调节中起到了轻微但重要的作用.
- 调解分析表明TMAO和功能之间存在因果关系,在临床前模型中,TMAO暴露加剧了脏痕.
- 接受保护性降血糖药物的患者表现出明显较低的TMAO水平.
结论:
- 功能和TMAO水平之间存在双向关系.
- 保护性抗糖尿病药物可能是减少TMAO的临床可行的策略.
- 向功能可以提供一种新的方法来降低与TMAO相关的心血管风险.
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