在患有凝血酶阴性斯塔菲洛可克菌病的患者中发生内心炎的风险
Antonio Ramos-Martínez1, Patricia González-Merino2, Elena Suanzes-Martín2
1Internal Medicine Department, Infectious Diseases Unit, Autonomous University of Madrid, Instituto Investigación Sanitaria Puerta de Hierro - Segovia de Arana (IDIPHSA), Hospital Universitario Puerta de Hierro, C/ Maestro Rodrigo 2, 28222, Majadahonda, Spain. aramos220@gmail.com.
Scientific reports
|September 20, 2023
概括
凝聚性阴性葡萄球菌 (CoNS) 细菌病可能表明感染性内心炎 (IE),特别是在假体门患者中. 持续的细菌血症和门假肢是排除IE与心声学关键指标.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 医学微生物学 医学微生物学
背景情况:
- 凝聚酶阴性葡萄球菌 (CoNS) 是感染性内心炎 (IE) 的常见原因,特别是在假体心脏膜患者中.
- 在患有CONS细菌病的患者中确定IE的危险因素对于及时诊断和治疗至关重要.
研究的目的:
- 为了确定与感染性内心炎 (IE) 相关的临床变量,在患有凝结酶阴性葡萄球菌 (CoNS) 细菌病的患者中.
- 在一组患有 CoNS 细菌病的患者中确定IE 的预测因子.
主要方法:
- 回顾性分析来自于入院于大学医院的CONS细菌病患者的临床数据.
- 对细菌血症注册的评估,包括心声图的结果和血液培养时间.
- 多变量分析以确定IE的独立预测因素.
主要成果:
- 在106名患有CONS细菌病的患者中,12名 (14.2%) 符合IE标准. 带假的患者IE发病率显著高 (83.3%).
- 持续性细菌血症 (阳性血液培养>12小时) 与IE独立相关 (OR 2.6).
- 使用门假体与IE (OR 38.6) 有着强烈的关联,IE患者的可归因死亡率更高.
结论:
- 很大一部分CoNS细菌性病例与感染性内心炎有关.
- 膜假肢的存在和持续的细菌病是怀疑IE的关键指标.
- 应在患有CoNS细菌病的患者进行心声扫描,特别是那些带有门假体或长期阳性血液培养的患者,以排除或确认IE.
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