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Updated: Jul 16, 2025

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在KRASG12D驱动的肺腺癌中,SOS1对于瘤发育和微环境调节的关键要求是G12D

Fernando C Baltanás1,2, Rósula García-Navas3, Pablo Rodríguez-Ramos3

  • 1Lab 1. Cancer Research Center, Institute of Cancer Molecular and Cellular Biology, CSIC-University of Salamanca and CIBERONC, 37007, Salamanca, Spain. fcalvo@us.es.

Nature communications
|September 20, 2023
PubMed
概括

向SOS1显著改善KRAS驱动的G12D肺腺癌 (LUAD) 的存活率,通过减少瘤负担和改变瘤微环境 (TME). 这凸显了SOS1作为LUAD的关键治疗点.

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