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Updated: Jul 16, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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一个紧的CRISPR-Cas13核酶激活的结构基础

Xiangyu Deng1, Emmanuel Osikpa2, Jie Yang2

  • 1Department of BioSciences, Rice University, Houston, TX, 77005, USA.

Nature communications
|September 20, 2023
PubMed
概括

研究人员特征了一种紧的CRISPR-Cas13变体 (Cas13bt3),用于腺相关病毒传递. 这种变体显示出独特的RNA裂变和激活机制,使得工程版本可以减少治疗应用的目标外效应.

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