根据2016年氧化查指南的趋势和做法
Fritz Gerald P Kalaw1,2,3, Justin Arnett1, Sally L Baxter1,3,4
1Viterbi Family Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, 9415, Campus Point Drive, La Jolla, CA, 92093, USA.
Scientific reports
|September 20, 2023
概括
氧化的查显示了眼科医生之间显著的差异,许多患者接受更高的剂量和不充分的视野测试,特别是亚洲患者. 这凸显了需要更好地遵守美国眼科学院的指导方针,以防止毒性.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧化 (HCQ) 广泛用于治疗自身免疫性疾病,如狼和类风湿性关节炎.
- 眼部毒性是与HCQ相关的已知风险,需要定期查.
- 美国眼科学会 (AAO) 在2016年更新了查指南.
研究的目的:
- 为了描述HCQ用户,推模式和剂量.
- 评估各种眼科医生是否遵守2016年AAO查指南.
- 识别查实践中的差异,特别是不同种族群体的视野测试.
主要方法:
- 对166名处方HCQ的患者进行电子健康记录 (EHR) 的回顾性审查.
- 数据收集包括患者人口统计学,HCQ指示和剂量,管理提供者类型和使用的成像方式.
- 分析的重点是遵守AAO查指南.
主要成果:
- 常见的适应症:全身性红斑狼 (52.4%),类风湿性关节炎 (18.7%).
- 超过一半的患者 (55.4%) 接受了高于推的HCQ剂量 (>5 mg/kg/天),特别是那些体重较低的患者.
- 视觉实地测试的坚持率很低 (亚洲患者的8.3%,非亚洲患者的71.1%) 视网膜专家表现出更好地遵守整体查方式.
结论:
- 与当前的AAO建议相比,HCQ的处方和眼科查实践存在显著的变化.
- 对亚洲患者进行适当的视野测试存在严重缺陷.
- 调查结果强调需要采取干预措施,以加强HCQ毒性查协议和指导方针的遵守.
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