对Ligilactobacillus agilis BKN88对肠道衍生物质的负化学作用
Shunya Suzuki1,2, Kenji Yokota1, Shizunobu Igimi1
1Department of Agricultural Chemistry, Graduate School of Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya, Tokyo, 156-8502, Japan.
Scientific reports
|September 21, 2023
概括
敏菌 Ligilactobacillus agilis 使用运动性和化学反应来导航肠道,感知酸和胆汁等驱虫剂. 它的多种化疗受体显示功能冗余,有助于胃肠道的生存.
科学领域:
- 微生物学 微生物学
- 细菌生理学 细菌生理学
- 化学反应的化学作用.
背景情况:
- 酸菌 (Ligilactobacillus agilis) 是一种移动的乳酸细菌,生活在动物的胃肠道中.
- 以前的研究表明,L. agilis的运动性有助于小鼠模型中的肠道殖民.
- 移动乳酸菌的化学作用能力以前没有被描述.
研究的目的:
- 在L. agilis BKN88.88.中识别肠道衍生化学效应物及其相应的化学受体.
- 阐明化疗在L. agilis.生存和殖民中的作用.
- 为了比较移动和非移动乳酸菌的生存策略.
主要方法:
- 使用野生型和突变 (ΔcheA) L. agilis 菌株进行了化学试验.
- 测试了包括低pH值,有机酸和胆汁盐在内的各种肠道衍生化合物作为化疗效应.
- 分析了突变菌株与删除的假定化学受体基因 (mcp1-mcp5).
主要成果:
- 低pH值,有机酸和胆盐被确定为对L. agilis.的驱逐剂.
- 与非移动乳酸菌相比,L. agilis BKN88对胆汁和酸具有更高的敏感性.
- 所有五个已识别的化疗受体 (mcp1-mcp5) 都感知到多个化疗因子,并显示功能冗余,Mcp2和Mcp3特别通用.
结论:
- L. agilis很可能利用机动性和化学反应来适应肠道,而不是仅仅依靠抗压力.
- 已识别的化学受体及其连接体相互作用为移动乳酸菌的生态利基提供了洞察力.
- 移动乳酸菌与其非移动的对应物相比,可能具有不同的生态和进化特征.
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