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在体内使用AAV-Perturb-seq进行转录链接分析

Antonio J Santinha1, Esther Klingler2,3, Maria Kuhn1,4

  • 1Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

Nature
|September 21, 2023
PubMed
概括

一种名为AAV-Perturb-seq的新方法可以在体内对基因功能进行高吞吐量研究. 这种方法确定了22q11.2删除综合征的关键基因,揭示了神经元功能障碍和潜在的治疗点.

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RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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