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自动抗体阳性的结构和功能差异与慢性甲状腺炎的自动抗体阴性的甲状腺功能低下患者相比
Yuichiro Iwamoto1, Tomohiko Kimura2, Takashi Itoh2
1Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan. iwamoto.g@med.kawasaki-m.ac.jp.
Scientific reports
|September 21, 2023
概括
甲状腺功能低下病例中很大一部分 (34.6%) 缺乏甲状腺自身抗体. 与抗体阳性病例相比,抗体阴性低甲状腺症通常表现为较小的甲状腺和较低的TSH水平.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 甲状腺学 甲状腺学
背景情况:
- 大多数成人原发性甲状腺功能低下症源于慢性甲状腺炎,通常涉及抗甲状腺蛋白抗体 (TgAb) 和抗甲状腺过氧化酶抗体 (TPOAb) 等自身抗体.
- 抗体阴性甲状腺功能低下症的临床特征尚不清楚,需要进一步调查其患病率和特征.
研究的目的:
- 确定诊断为初级甲状腺功能低下症的患者甲状腺相关自身抗体的患病率.
- 为了比较抗体阳性和抗体阴性低甲状腺症患者之间的甲状腺结构和激素水平.
主要方法:
- 804名患有甲状腺异常或扩大症的患者的回顾性分析.
- 包括237名患有原发性甲状腺功能低下症的患者,他们接受了甲状腺抗体检测和超声波.
- 将患者分为抗体阳性和抗体阴性组进行对比分析.
主要成果:
- 34.6%的患者出现了抗体阴性甲状腺功能低下症.
- 对TgAb和TPOAb的阳性率分别为62.0%和49.4%.
- 与抗体阴性病例相比,抗体阳性低甲状腺症与显著更大的甲状腺 (p <0.05) 和更高的甲状腺刺激激素 (TSH) 水平有关.
结论:
- 抗体阴性慢性甲状腺炎的患病率在甲状腺功能低下患者中很大.
- 抗体阳性和抗体阴性甲状腺功能低下症之间存在甲状腺结构和TSH水平的显著差异.
- 研究结果为治疗抗体阴性甲状腺功能低下患者提供了洞察力,尽管需要进一步的研究.
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