在怀疑轴性脊柱关节炎的患者中,基于T1加权图像的放射学用于结构性损伤的评估
Mo Zheng1, Guanxia Zhu2, Dan Chen3
1Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, Zhejiang, China.
La Radiologia medica
|September 21, 2023
概括
使用T1加权图像 (T1WI) 的放射学分析显示,在疑似轴性脊柱关节炎 (axSpA) 中检测神经关节 (SIJ) 结构性损伤具有前途. 这种方法实现了专家级别的性能,将放射性特征与特定病变相关联,从而实现了潜在的智能诊断.
科学领域:
- 医疗成像医学成像
- 放射学 放射学是一门学科.
- 人工智能在医学中的应用
背景情况:
- 轴脊椎关节炎 (axSpA) 涉及关节 (SIJ) 炎症和结构损伤.
- 精确评估SIJ结构性损伤对于axSpA诊断和管理至关重要.
- 目前的成像方法在全面评估这些病变方面存在局限性.
研究的目的:
- 评估使用T1加权MRI (T1WI) 评估放射学可行性,以检测疑似axSpA.患者的SIJ结构损伤.
- 与专家阅读器相比,评估放射学模型的诊断性能.
- 探索放射性特征与特定类型的SIJ结构性损伤之间的相关性.
主要方法:
- 一组266名疑似axSpA患者接受了低剂量CT (ldCT) 和MRI.
- 从SIJ T1WI中提取了放射性特征,以开发放射性模型.
- 模型性能使用接收器操作特征 (ROC) 曲线进行评估,以 ldCT 为参考标准.
- 点-二序相关性分析调查了放射性特征和结构性损伤之间的关联.
主要成果:
- 放射学模型在检测全球SIJ结构损伤方面表现良好 (在培训和验证队列中AUC为0.82).
- 该模型的性能超过了经验丰富的MRI评级者 (AUC 0.73-0.74).
- 七个放射性特征与结构性损伤有显著的相关性 (P <0.05),波形.LHL_firstorder_90Percentile显示与脂肪损伤的最强相关性 (r=0.48).
结论:
- 对T1WI的放射学分析对于在疑似axSpA中检测SIJ结构性损伤是有效的,实现了专家级别的性能.
- 个别的放射性特征与特定的结构性损伤有显著的相关性.
- 这些发现支持放射学在智能 axSpA 诊断方面的潜力.
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