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在儿科急性淋巴细胞白血病中,环林D2基因变异和表达水平

Reham Abdel Haleem Abo Elwafa¹, Magdy El Bordiny¹, Mostafa Salama²

¹Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Pediatric blood & cancer

|September 21, 2023

概括

CCND2 rs3217927单核酸多态 (SNP) 的G基因基因与埃及儿童患急性淋巴细胞白血病 (ALL) 的风险较高有关. 这种CCND2 SNP还可以作为所有风险分层和治疗结果的负预后标记.

科学领域:

遗传学是一个遗传学.
在瘤学瘤学.
分子生物学分子生物学

背景情况:

环素D2 (CCND2) 在细胞循环调节中起着至关重要的作用.
CCND2中的多态性与癌症倾向有关.

研究的目的:

研究CCND2 rs3217927单核酸多态 (SNP) 及其表达水平与埃及儿童急性淋巴细胞白血病 (ALL) 易感性之间的关联.
确定这个CCND2 SNP在儿科ALL中的潜在预后价值.

主要方法:

在80名儿科ALL患者和80名对照中使用5'核酶等位基因歧视试验对CCND2 rs3217927 SNP进行基因定型.
通过实时定量聚合酶链反应量化CCND2相对表达水平的量化.

主要成果:

在ALL患者中,CCND2 rs3217927的GG基因型和G等位基因显著更频繁 (p < .001).
携带单个G等位基因的ALL风险与携带A等位基因的人相比增加了大约31倍.
在ALL患者中,CCND2过度表达 (p < .001),与GG基因型和G等位基因相关.
G基因组独立地预测了负面的预后结果,包括中枢神经系统的参与 (OR = 4.676),更高的风险分层 (OR = 38) 和化学抵抗 (OR = 9.864).

结论:

CCND2 rs3217927 SNP的G等位基因与埃及儿童ALL风险增加有关.
这种CCND2 SNP作为独立的负预后标志物,用于儿童ALL的风险分层和治疗结果.
对CCND2 rs3217927的基因定型可能有助于识别所有具有攻击性疾病表型的患者,以便针对性治疗.

关键词:

所有的,所有的,所有的.环林 D2 的使用.表达方式表达方式表达方式表达儿科儿科儿科儿科需要 rs321792727 的钱.

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