随机对照试验的Jiandu颗粒在预防化学放射治疗诱导的口腔粘膜炎
Huakang Li1, Jianlong Ke1, Xiaoyan Wang2
1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Oral diseases
|September 21, 2023
概括
在接受化疗或放射治疗的鼻癌患者中,Jiandu颗粒显著降低了严重的口腔粘膜炎. 这种中国草药表现出良好的安全性,提供了有前途的预防方案.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 综合医学是一个整体的医学.
背景情况:
- 同时接受化疗放射治疗 (CCRT) 的鼻癌 (NPC) 患者面临严重口腔粘膜炎 (SOM) 的高风险.
- 口腔粘膜炎显著影响治疗的坚持和生活质量.
- 对NPC患者的SOM有效的预防策略至关重要.
研究的目的:
- 为了评估Jiandu颗粒的疗效和安全性,一个中国草药,预防SOM.
- 评估Jiandu颗粒对口腔粘膜炎的发生率和严重性的影响.
- 确定Jiandu颗粒在这个患者群体中的安全性.
主要方法:
- 一个单中心,开放标签,随机对照试验与138位局部晚期NPC患者进行.
- 在CCRT期间,患者接受了标准护理加Jiandu颗粒 (实验组) 或单独接受标准护理 (对照组).
- 主要结局是严重口腔粘膜炎 (III-IV级) 的发生率.
主要成果:
- 与对照组 (44.9%) 相比,在Jiandu颗粒组 (20.3%) 中,SOM的发病率明显较低.
- 在SOM (p=0.002) 中,Jiandu颗粒显示出显著的绝对风险降低 (24.6%) 和相对风险降低 (54.8%).
- 这种干预与轻度/中度胃肠道反应发病率低 (5.9%).
结论:
- 在接受CCRT的NPC患者中,Jiandu颗粒有效降低严重口腔粘膜炎的发生率.
- 这种草药配方对这个患者群体具有可接受的安全性.
- 在瘤治疗中,Jiandu颗粒代表了一种潜在的有价值的治疗选择,用于治疗口腔粘膜炎.
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