合成大麻素在头发中-在德国驾驶执照重新颁发的禁欲控制计划中使用的普遍性
Johannes Kutzler1,2,3,4, Aldo Eliano Polettini1,5, Sergej Bleicher1
1Department of Forensic Toxicology & Drug Analysis, SYNLAB MVZ Weiden GmbH, Weiden, Germany.
Drug testing and analysis
|September 21, 2023
概括
合成大麻素 (SC) 的使用在禁欲控制计划中很普遍,3.6%的头发样本检测呈阳性. 在头发分析中进行常规的SC查对于检测新兴药物类型和防止大麻替代是必不可少的.
科学领域:
- 法医毒理学 法医毒理学
- 药物分析 药物分析
- 药理学 药理学是指药理学的学科.
背景情况:
- 合成大麻素 (SCs) 显示出越来越多的市场流行和结构多样性.
- 在驾驶执照重新授予的禁欲控制计划中,SC分析的代表性不足.
- 监测SC使用对于公共健康和安全至关重要.
研究的目的:
- 为了确定合成大麻素 (SCs) 在来自德国禁欲控制计划的头发样本中的患病率.
- 为了确定被监测的个体使用的特定的SC和新型类型.
- 在这些计划中评估当前SC查方法的充分性.
主要方法:
- 分析了从2020年3月到2021年3月收集的头发样本 (n=5097).
- 进行了滥用药物的定量分析和107个SC的定性分析.
- 液体染色学-双重质谱学 (LC-MS/MS) 和飞行质谱学的LC-高分辨率时间 (LC-qTOF/MS) 用于新型SCs的查和识别.
主要成果:
- 在44个不同的SC中发现了181个SC检测 (3.6%).
- 5F-MDMB-PICA和MDMB-4en-PINACA是检测到的最常见的SCs.
- 通过使用LC-qTOF/MS识别了10种最初未被LC-MS/MS覆盖的新型SC类似物.
结论:
- 头发样本分析是监测SC使用在禁欲控制计划中的有效方法.
- 检测到的SCs的患病率与可卡因和安非他林的患病率相当.
- 建议在头发分析中进行常规和更新的SC查,以解决新出现的类型,并防止取代大麻.
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