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相关概念视频

DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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在IlluminaDNA甲基化中的幻灯片效应的一致模式BeadChip数据阵列数据阵列.

Julian Hecker1, Sanghun Lee1,2,3, Priyadarshini Kachroo1

  • 1Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Epigenetics
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概括

使用DNA甲基化阵列的表观遗传学研究面临批量效应带来的挑战. 这项研究确定了Illumina甲基化EPIC阵列上的幻灯片效应的系统模式,改进了复杂疾病的数据分析.

关键词:
通过DNA甲基化.欧洲经济联盟 (EWAS) 的成员.批量效应 批量效应 批量效应甲基化阵列中的甲基化阵列.幻灯片效果的幻灯片效果是什么

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科学领域:

  • 遗传学 是一个遗传学.
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 数以千计的DNA甲基化CpG与复杂疾病的关联凸显了表观遗传学的作用.
  • 甲基化阵列分析易受批量/幻灯片效应的影响,影响准确性.
  • 这些影响可能会增加假阳性率或降低关联研究中的统计能力.

研究的目的:

  • 在CpG中描述一致的模式和幻灯片效应的联合分布.
  • 通过使用Illumina Infinium MethylationEPIC BeadChip阵列来扩展之前关于幻灯片效应的发现.
  • 为改善现有的甲基化数据调整方法提供见解.

主要方法:

  • 来自Illumina Infinium MethylationEPIC BeadChip阵列的多个DNA甲基化数据集的分析.
  • 在幻灯片效果中识别和描述一致的模式.
  • 在CpG中检查幻灯片效应的联合分布.

主要成果:

  • 在CpG中观察到一致的模式和幻灯片效应的联合分布.
  • 受幻灯片效应影响的CPG与Illumina Infinium HumanMethylation450 BeadChip阵列中的内容重叠.
  • 揭示了幻灯片效应的系统模式,证实并扩展了先前的研究.

结论:

  • 该研究揭示了DNA甲基化数据中的幻灯片效应的系统模式.
  • 这些发现为幻灯片效应的特征提供了更深入的见解.
  • 结果可以帮助改进和改进当前的方法来调整这些影响在分析.