针对艾滋病毒感染者的SARS-CoV-2疫苗免疫性:系统性审查和元分析
Mads Herluf Søndergaard1, Jannifer Jasmin Thavarajah1, Henry Churchill Henson2
1Faculty of Health, Aarhus University, Aarhus C, Region Midtjylland, Denmark.
HIV medicine
|September 21, 2023
概括
艾滋病毒感染者 (PLWH) 的COVID-19疫苗免疫性是有利的,特别是在第三剂和有效的艾滋病毒治疗后. 需要进一步的研究来了解影响PLWH抗体反应的因素.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 关于艾滋病毒感染者 (PLWH) 的SARS-CoV-2疫苗免疫性存在不一致的发现.
- 缺乏专门针对PLWH第三剂SARS-CoV-2疫苗免疫性进行的元分析.
- 确定PLWH中抗体反应的驱动因素对于优化疫苗接种策略至关重要.
研究的目的:
- 在PLWH中系统地审查和元分析SARS-CoV-2疫苗的免疫性.
- 确定影响PLWH中对SARS-CoV-2疫苗抗体反应的因素.
- 为此群体提供疫苗有效性的全面概述.
主要方法:
- 使用PubMed,Embase和Web of Science数据库进行了系统审查.
- 包括报告免疫球蛋白G (IgG) 或中和抗体生产在疫苗接种后的PLWH的研究.
- 一项元分析汇总了来自59项研究的数据,并对疫苗类型和剂量进行了子组分析.
主要成果:
- 在 SARS-CoV-2 疫苗接种后,在 10,343 名 PLWH 中观察到 87.09% 的综合血清反应.
- 除了非活化疫苗,8053个PLWH的综合反应增加到91.62%.
- 在1974年的PLWH中,第三剂疫苗的综合反应为92.35%,在CD4计数,病毒载量和年龄方面发现的相关性较弱.
结论:
- 在PLWH中,SARS-CoV-2疫苗显示出有利的免疫效应.
- 第三剂疫苗和有效的艾滋病毒治疗对于PLWH的最佳免疫性至关重要.
- 需要进行进一步的研究,以充分阐明CD4计数和病毒载荷等因素对疫苗反应的影响.
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