生物治疗类风湿性关节炎中多维疲劳的横截面研究:哪些变量起作用?
Alexandra Husivargova1,2, Vladimira Timkova1, Zelmira Macejova3
1Department of Social and Behavioural Medicine, Faculty of Medicine, PJ Safarik University, Kosice, Slovakia.
Disability and rehabilitation
|September 21, 2023
概括
风湿性关节炎 (RA) 患者服用生物修饰性抗风湿药物 (bDMARD) 经历了显著的疲劳. 疼痛和焦虑分别与身体和精神疲劳有关,需要个性化治疗策略.
科学领域:
- 类风湿病学 类风湿病学
- 心理学 心理学 心理学
背景情况:
- 风湿性关节炎 (RA) 患者经常经历持续的疲劳,尽管治疗生物修饰性抗风湿药物 (bDMARDs).
- 了解疲劳的具体维度及其贡献因素对于改善患者的治疗结果至关重要.
研究的目的:
- 为了评估bDMARDs治疗的RA患者不同疲劳尺寸的严重程度.
- 在这个患者群体中调查疲劳,疼痛,睡眠质量和心理健康之间的关联.
主要方法:
- 一组146名接受bDMARDs的RA患者完成了评估疲劳 (MFI-20),整体健康 (SF-36),睡眠质量 (PSQI),焦虑 (GAD-7) 和抑郁 (PHQ-9) 的验证问卷.
- 使用相关性分析和多重线性回归模型来分析变量之间的关系.
主要成果:
- 总体和身体疲劳是患者报告的最常见的维度.
- 疼痛和残疾显著与身体疲劳和活动减少有关.
- 焦虑与精神疲劳和动力减少有显著的关联.
- 在分析的模型中,没有发现抑郁症,睡眠质量和疲劳之间的显著关联.
结论:
- 在服用bDMARD的RA患者中,疲劳是多方面的,其严重程度在身体和精神方面各不相同.
- 一个个性化的治疗方法是必不可少的,考虑到患者特定的因素,如疼痛,残疾和心理痛苦 (焦虑).
- 目前的治疗策略可能需要改进,以更好地解决RA疲劳的复杂性质.
相关概念视频
01:11Genome-wide Association Studies-GWAS
13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.6K
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
37
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
37
01:21Fatigue
199
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
199
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
164
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
164
01:21Rheumatic Heart Disease III: Medical Management
11
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
11