基于测序的转录组分析显示,与高度CIN相比,早期宫癌的免疫反应和血管生成相关表达模式的多样化与高度CIN相比
Olga V Kurmyshkina1, Pavel V Dobrynin2, Pavel I Kovchur3,4
1Laboratory of Molecular Genetics of Innate Immunity, Institute of Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
Frontiers in immunology
|September 21, 2023
概括
早期的宫癌显示出影响免疫反应和血管生成的多种分子模式. 了解这些差异可以改善与病毒相关的宫癌的向治疗方法.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 与病毒相关的宫癌的分子多样性,特别是早期的免疫和血管性特征,尚不清楚.
- 描述这些特征可以提供关于瘤攻击性,治疗反应和预后的见解.
研究的目的:
- 在早期的宫癌中识别转录组景观.
- 将这些景观与前体病变进行比较,重点关注免疫特征,信号通路和微环境组成.
主要方法:
- 人类乳头瘤病毒阳性宫内皮质瘤 (CIN),早期侵袭性宫癌 (FIGO IA1-IIB) 和正常的宫上皮的RNA测序.
- 转录组形状的生物信息分析,包括信号通路激活,免疫细胞分布和基因组区域分析.
主要成果:
- 层次聚类揭示了三个不同的基因表达模式,将癌前病变与早期侵袭性癌症分开.
- 基因组丰富分析显示,与CIN相比,瘤组之间的免疫和血管性质存在显著差异.
- 细胞组成分析表明,免疫和 stromal 区间的影响有所变化,转录组差异与染色体区域有关,这些区域参与免疫调节和瘤入侵.
结论:
- 早期宫癌中明显的转录组模式突出显示了免疫反应和血管生成在瘤入侵和进展中的多种作用.
- 这些发现可能会导致对与病毒相关的宫癌的针对性抗血管原体和基于免疫的疗法得到改善.
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