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喘成人血清铁和血中乙氨基酸细胞数量之间的关系:来自NHANES 2011-2018年的数据
Jun Wen1, Changfen Wang2, Jing Xia3
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
血清铁含量较高与患有喘的成年人血液中乙氨基酸细胞数量较低有关. 这表明铁可能会影响喘.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 营养科学 营养科学
背景情况:
- 系统铁水平与喘相关的炎症有关,但研究结果不一致.
- 很少有研究探讨了喘时血清铁和血中乙酸细胞计数之间的联系.
- 这项研究调查了喘患者血清铁和血中乙酸细胞计数之间的关联.
研究的目的:
- 探索血清铁含量与患有喘的成年人血液中乙氨基酸细胞计数之间的联系.
- 在喘患者群体中识别可能影响血中乙氨基酸细胞数量的潜在影响因素.
- 提供关于铁在喘管理和治疗中的作用的见解.
主要方法:
- 利用了2011-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 包括2549名被诊断患有喘的成年参与者.
- 采用多变量线性回归,XGBoost机器学习,通用添加模型,以及分析的断片线性回归.
主要成果:
- 在患有喘的成年人中,血清铁含量和血液中乙氨基酸细胞数量之间发现了显著的反向线性关联.
- 血清铁 (μmol/L) 的每一个单位增加对应于血中异氨基酸细胞数量的1.41 /μL下降.
- XGBoost分析确定了维生素C摄入量,年龄,维生素B12摄入量,铁摄入量和血清铁作为血红蛋白细胞计数的关键预测指标.
结论:
- 血清铁含量与患有喘的成年人的血中乙氨基酸细胞数量相反相关.
- 这一发现表明血清铁可能在调节喘患者的免疫状况方面发挥作用.
- 进一步研究铁在喘发作,进展和治疗中的作用是有必要的.
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