在患有血液性恶性败血性休克的患者中,使用oXiris®的连续替代疗法:一项回顾性研究
Juan Wang1, Shu-Run Wei1, Tong Ding1
1Intensive Care Unit, Hebei Yanda Hospital, Langfang 065201, Hebei Province, China.
World journal of clinical cases
|September 21, 2023
概括
使用oXiris血过器的连续置换疗法 (CRRT) 可能会缩短血液恶性病和败血性休克患者的复苏时间. 这种疗法还有助于减少炎症媒介和液体平衡,改善患者的治疗结果.
科学领域:
- 关键护理医学 关键护理医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
背景情况:
- 患有血液性恶性瘤 (HM) 的患者患有感染性休克的死亡率较高.
- 由于免疫功能受损的状态,长时间的复苏是有害的.
- 使用oXiris血过器的连续置换疗法 (CRRT) 是缩短复苏时间的潜在策略.
研究的目的:
- 为了评估CRRT与oxiris血过器在缩短复苏时间方面的有效性.
- 评估oXiris血过器对降低炎症介质水平的影响.
- 在HM和败血性休克患者中修改宿主反应.
主要方法:
- 分析了45名接受CRRT的HM和败血症休克患者的队列.
- 患者被分为两个组:oXiris血过器 (n=26) 和M150血过器 (n=19).
- 进行比较的关键参数包括液体平衡,心率,北上腺素剂量,SOFA分数和乳酸水平. 在oxiris组中测量了炎症媒介.
主要成果:
- 与M150组相比,oXiris组在CRRT7天后显示出明显较低的总流体平衡.
- 序列器官衰竭评估 (SOFA) 评分和乳酸水平在CRRT后的oXiris组显著下降.
- 在oXiris组中,前citonin,介素-6和瘤亡因子水平显著下降,这表明炎症减少.
结论:
- 使用oXiris血过器的CRRT可以通过减轻炎症媒介来增强血液动力稳定性.
- 这种方法在缩短复苏期和减少HM的败血症休克患者的液体平衡方面显示出潜力.
- oXiris血过器代表了在这个脆弱的患者群体中管理败血症休克的有希望的治疗选择.
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