在 hrHPV 感染中对宫和阴道微生物组的生态动态进行纵向分析
Mariano A Molina1,2, Willem J G Melchers1, Karolina M Andralojc1
1Department of Medical Microbiology, Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands.
Computational and structural biotechnology journal
|September 21, 2023
概括
宫和阴道的微生物组
科学领域:
- 微生物组研究的研究.
- 妇科卫生健康 妇科卫生健康
- 人类乳头瘤病毒 (HPV) 感染
背景情况:
- 宫-阴道微生物组 (CVM) 影响女性的宫健康.
- 缺乏乳杆菌的社区与对高风险HPV (hrHPV) 感染和疾病进展的敏感性增加有关.
- 在hrHPV诊断后,CVM微生物社区状态类型 (CST) 的长期动态尚不清楚.
研究的目的:
- 调查 hrHPV 感染的女性中 CST 的长期生态动态.
- 为了将CVM组成和多样性与hrHPV持久性和疾病进展相关联.
- 确定与CVM稳定性和转变相关的特定微生物物种.
主要方法:
- 在141名被诊断为 hrHPV 感染的妇女中进行了长度队列研究.
- 在基线和六个月间收集的宫涂片用于微生物组分析.
- 微生物社区状态类型 (CST) 和物种丰度的分析.
主要成果:
- 微生物组的不相似性与微生物多样性正相关.
- 与乳杆菌贫乏社区相比,具有主导性乳杆菌内置者的女性显示出更稳定的CVM组成.
- 乳杆菌酸性和Megasphaera基因组类型1与CST变化相关.
- Gardnerella vaginalis与稳定的乳杆菌贫乏群体相关;L. iners与不稳定的M. genomosp类型1群体相关.
结论:
- 宫性阴道CST在 hrHPV感染期间表现出动态模式.
- 微生物组的组成和多样性影响hrHPV感染的结果.
- 这些发现表明,基于微生物组的疗法有可能预防与 hrHPV 相关的疾病进展.
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