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相关概念视频

Carbon-13 (¹³C) NMR: Overview01:10

Carbon-13 (¹³C) NMR: Overview

5.8K
Carbon-13 is a naturally occurring NMR-active isotope of carbon with a low natural abundance of 1.1%. In contrast, carbon-12 is the most abundant isotope of carbon with zero nuclear spin. Therefore, it is NMR inactive. The gyromagnetic ratio of carbon-13 is smaller than that of protons. As a result, carbon-13 resonance is about 6000 times weaker than proton resonance. For a given magnetic field strength, the resonance frequency of carbon-13 is about one-fourth of the resonance frequency for...
5.8K
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

1.1K
When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.1K
¹³C NMR: ¹H–¹³C Decoupling01:04

¹³C NMR: ¹H–¹³C Decoupling

1.1K
The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
1.1K

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相关实验视频

Updated: Jul 16, 2025

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy
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Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy

Published on: April 21, 2023

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超极化[1-13C]pyruvate MRI 人体研究的当前方法

Peder Ez Larson1,2, Jenna Ml Bernard1, James A Bankson3

  • 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA.

ArXiv
|September 21, 2023
PubMed
概括

超极化13CMRI使用专门的药物来测量癌症等疾病中的新陈代谢. 本指南详细介绍了使用13C-pyruvate,一个关键的代谢标记物的人类研究的最佳实践.

关键词:
超极化核磁共振成像 (MRI) 是一种超极化的核磁共振成像.碳-13是什么意思溶解动态的核极化 动态的核极化代谢成像 - - 代谢成像皮鲁酸是一种酸盐.

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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

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相关实验视频

Last Updated: Jul 16, 2025

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy
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Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy

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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
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Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

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科学领域:

  • 医疗成像医学成像
  • 代谢成像 - 代谢成像
  • 生物物理学的生物物理.

背景情况:

  • 超极化 (HP) 13C MRI测量局部代谢在癌症,肝脏,心脏和脏等疾病中发生的变化.
  • 使用HP 13CMRI进行的人类研究在过去十年中迅速增长,这是由于改进的药剂制备方法.
  • 这种技术提供了对体内代谢过程的洞察,对于疾病诊断和监测至关重要.

结论:

  • 惠普13CMRI,特别是[1-13C]酸盐,是人类疾病代谢成像的强大工具.
  • 建立关于最佳实践的共识对于这种技术的持续进步和临床转化至关重要.
  • 这项工作作为未来研究和在超极化MRI领域达成共识的基础参考.