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Updated: Jul 16, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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基于piperidine/piperazine的化合物的发现和计算研究,这些化合物具有西格玛受体亲和力

Laura De Luca1, Lisa Lombardo1, Salvatore Mirabile1

  • 1Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina Viale Ferdinando d'Alcontres 31 98166 Messina Italy rgitto@unime.it.

RSC medicinal chemistry
|September 21, 2023
PubMed
概括

研究人员通过化合物选确定了一个强大的西格玛受体1 (S1R) 配体,化合物1. 这种S1R激动剂表现出高亲和力,其结合模式是用计算方法阐明未来的药物设计.

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