梅博姆腺体的形态变异:根据年龄分布以及上下眼之间的差异
Saumya Srivastav1, Mohammed Hasnat Ali2,3, Sayan Basu4
1Centre for Ocular Regeneration, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Frontiers in medicine
|September 21, 2023
概括
健康个体的梅博姆腺体形态表现出与年龄相关的变化,特别是腺体长度. 梅博姆腺的缩短随着年龄的增长而更加普遍,影响了膜的稳定性.
科学领域:
- 眼科医生 眼科 眼科
- 人体解剖学 解剖学 解剖学
- 老年学是一门学科.
背景情况:
- 梅博姆腺对眼睛表面的健康至关重要,产生稳定膜的脂质.
- 了解Meibomian腺形态变化与年龄的变化对于诊断和管理干眼疾病至关重要.
研究的目的:
- 研究不同年龄组的健康个体中各种梅博姆腺形态的分布和流行情况.
- 为了识别Meibomian腺结构的与年龄相关的变化.
主要方法:
- 红外美博图被用来评估Meibomian腺体形态在236个健康的个体 (472眼睛) 10至80岁的年龄.
- 进行了统计分析,包括线性混合效应建模,以评估跨年龄几十年的流行率和差异.
主要成果:
- 虽然大多数异常形态没有显示出与年龄相关的显著差异,但30岁以上的个体更常见的是短的Meibomian腺体,并且中度到严重的短腺体随着年龄的增长而增加,特别是在上眼.
- 在所有年龄段,某些形态,如扭曲的,的和扭曲的腺体在上眼中比下眼更频繁.
- 下眼脱落和严重短的腺体与减少的非侵入性撕裂破裂时间 (NIBUT) 相相关.
结论:
- 异常的梅博姆腺形态可以存在于健康个体.
- 只有中度到严重短的梅博姆腺体,随着年龄的增长,异常特征显著增加,可能会影响膜功能.
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