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MYC-在线粒体疾病中的新兴参与者

Janne Purhonen^1,2, Juha Klefström^3,4,5, Jukka Kallijärvi^1,2

¹Folkhälsan Research Center, Helsinki, Finland.

Frontiers in cell and developmental biology

|September 21, 2023

概括

线粒体疾病破坏细胞代谢,导致MYC (c-MYC) 的上调. 这种转录因子在癌症中至关重要,可能通过影响OXPHOS缺乏细胞的细胞增殖和基因组稳定性来推动疾病的进展.

科学领域:

细胞的新陈代谢
线粒体生物学线粒体生物学
癌症生物学癌症生物学

背景情况:

线粒体是细胞代谢和生物过程的核心.
线粒体疾病会损害氧化酸化 (OXPHOS),导致类似于癌症华堡效应的代谢重新连接.
转录因子MYC (c-MYC) 调节与癌症和线粒体疾病相关的代谢途径.

研究的目的:

审查MYC调节的代谢途径.
为了检查线粒体疾病中的MYC表达.
探索OXPHOS缺乏如何引发MYC上调及其病原性影响.

主要方法:

对MYC调节的代谢途径的文献综述.
对线粒体疾病模型中MYC表达现象现有研究的分析.
对MYC在OXPHOS缺乏症中的作用的推测分析.

主要成果:

MYC调节关键的代谢途径,包括糖解,核酸生物合成和谷氨胺利用.
几种线粒体疾病模型显示MYC上调或相关的转录特征.
线粒体综合应激反应 (mt-ISR) 与MYC过度表达效应重叠.
高MYC水平可以促进复制压力,基因组不稳定性和亡.
有OXPHOS缺陷的细胞可能易受高MYC水平的影响,影响细胞周期进展和DNA损伤.

结论:

在线粒体疾病中MYC上调是一种潜在的致病驱动因素.
了解OXPHOS,MYC和细胞代谢之间的相互作用对于疾病洞察至关重要.
需要进一步的研究来阐明精确的机制和治疗潜力.

关键词:

华堡效应是什么? 华堡效应细胞衰老细胞衰老电子传输链中的电子传输链.线粒体的综合应激反应氧化酸化是一种氧化酸化.呼吸系统复合物III 呼吸系统复合物III

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