内镜查对胃癌死亡率降低的有效性
Naoki Ishii1, Yasutoshi Shiratori2, Masahiro Ishikane3
1Division of Gastroenterology Tokyo Shinagawa Hospital Tokyo Japan.
DEN open
|September 21, 2023
概括
胃癌内镜查在许多国家显示人口有效性有限. 查所需的高数量 (NNS) 和低死亡率降低表明在广泛实施之前需要仔细考虑.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 有限的随机对照试验存在于内镜胃癌查的有效性.
- 对于胃癌的内镜查的基于人口的证据是不够的.
- 评估查计划对现实世界的影响对于公共卫生政策至关重要.
研究的目的:
- 确定影响胃癌查人口有效性的因素.
- 估计需要查 (NNS) 的数量,以防止一个胃癌死亡.
- 评估184个国家的内镜查预期的死亡率降低.
主要方法:
- 进行了PubMed的快速审查,以确定内镜查与不进行查的相对风险,以减少死亡率.
- 确定了导致可归因风险,NNS和死亡率降低的因素.
- 使用聚合相对风险和GLOBOCAN数据计算了NNS和死亡率降低.
主要成果:
- 原始死亡率,查方式的有效性和查人口的比例影响了可归因风险,NNS和死亡率的降低.
- 内镜查显示,相对于没有查,聚合的相对风险为0.58.
- NNS从2522到91,575不等,预期的死亡率降低从0.2%到7.9% (每10万) 不等,查率为20%,因国家而异.
结论:
- 疾病负担和查率对于人口的有效性至关重要,以及模式的有效性.
- 高的NNS和低的死亡率降低表明,内镜查在许多国家可能不有效.
- 结果为决策提供了有价值的见解,关于实施内镜胃癌查计划.
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