沿阿尔茨海默氏症连续体的认知的基于表面的相关性在一个记忆诊所的人口中
Michelle M Coleman1, Cierra M Keith1,2, Kirk Wilhelmsen1,3
1Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, United States.
Frontiers in neurology
|September 21, 2023
概括
这项研究表明,大脑结构的变化,如皮质稀薄,与阿尔茨海默病 (AD) 患者的特定认知下降有关. 这些发现即使在记忆诊所的单个认知测试中也可以观察到.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 认知科学 认知科学
背景情况:
- 大规模的阿尔茨海默病 (AD) 研究通常使用复合认知测量和生物标记数据.
- 将这些发现转化为使用单一认知测量和没有生物标志物数据的记忆诊所人群仍然未得到充分探索.
- 之前的神经成像研究主要使用基于voxel的形态测量或有限的基于表面的形态测量 (例如皮质厚度).
研究的目的:
- 在记忆诊所队列中复制和扩展生物标志物-认知关系.
- 通过扩展表面形态测量 (SBM) 测量 (皮层厚度,状深度,化指数) 来研究这些关系.
- 使用单个与AD相关的认知指标,而不是复合得分.
主要方法:
- 检查了271名个人:轻度认知障碍 (MCI,N=93),阿尔茨海默病 (N=178),健康对照 (N=29).
- 应用SBM测量 (皮层厚度,层深度,化指数) 到AD的"标志性区域".
- 评估认知功能,包括口头学习,记忆保留,语言和执行功能.
主要成果:
- 时,额头和身区域的皮层厚度与口头学习,语言和执行功能相关联.
- 语言记忆的保留与时厚度和下部时回形转化有关.
- 语言与部区域,上边缘状层深度和化相关.
- 执行功能与中间状回形,上边状回形深度和状/上边状回形相关,但不涉及额头区域.
- 认知测量预测通常涉及中间状圈厚度和状深度.
结论:
- 皮质稀疏和认知之间的广泛关系在临床诊断的阿尔茨海默病人群中显而易见,这些人群使用单一的认知措施.
- 度深度和度指数的实用性可能更具体地适用于某些大脑区域和认知功能.
- 复制了时,额头和身区域对口头学习,语言和执行功能的重要性,但不是口头记忆的保留.
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