一项基于人群的研究,研究了患有腹腔大动脉动脉瘤和没有腹腔大动脉动脉瘤的男性的高胰岛素血症和动脉硬
Shahab Fatemi1,2, Stefan Acosta1,3, Moncef Zarrouk1,3
1Department of Clinical Sciences, Lund University, Malmö.
Cardiovascular endocrinology & metabolism
|September 21, 2023
概括
胰岛素抵抗,由更高的胰岛素水平表明,与65岁男性的腹腔大动脉动脉瘤 (AAA) 和更大的大动脉直径有关. 这种关联甚至在没有被诊断为糖尿病或增加动脉硬性的情况下也被观察到.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 2型糖尿病 (DM) 与腹腔大动脉动脉瘤 (AAA) 的风险降低有关.
- 了解葡萄糖代谢,胰岛素抵抗和AAA发展之间的关系对于风险分层至关重要.
- 在老年男性中研究这些因素是很重要的,因为在这个人口群体中AAA的患病率更高.
研究的目的:
- 评估65岁男性葡萄糖代谢障碍,动脉硬以及腹腔大动脉动脉瘤 (AAA) 的存在和直径之间的关联.
- 为了确定高胰岛素血症或高糖血症是否与AAA独立相关.
- 探索胰岛素抵抗标志物与腹部大动脉直径之间的联系.
主要方法:
- 一项以人口为基础的研究,涉及48名查检测到AAA的男性和115名正常腹腔大动脉直径的男性,所有人都65岁.
- 评估葡萄糖代谢 (包括口服葡萄糖耐受性测试-OGTT) 和动脉硬度.
- 对吸烟,腰比 (WHR) 和使用降脂剂等因素进行调整后的关联分析.
主要成果:
- 患有AAA的男性在OGTT后表现出更高的BMI,WHR,DM频率,HbA1c,吸烟暴露和血胰岛素水平.
- 在OGTT后血胰岛素的增加在AAA的男性中显著更高,即使在调整后.
- 在OGTT后2小时,血胰岛素增加和血类固醇水平升高与更大的腹腔大动脉直径有关,独立于其他因素.
- 两组之间在主动脉硬度或高级糖化最终产品方面没有发现显著差异.
结论:
- 胰岛素抗性的标志物高胰岛素血,与65岁男性的腹腔大动脉动脉瘤 (AAA) 和腹腔大动脉直径增加有关.
- 在这个队列中,高血糖和大动脉硬性没有发现与AAA独立相关.
- 这些发现表明,胰岛素抵抗可能在AAA病变发生过程中发挥作用,而不依赖于糖尿病状况或动脉硬.
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