在精神分裂症谱系障碍中,大麻使用与症状维度之间的关联:对3053个人进行个人参与者数据元分析
Mathilde Argote1,2,3, Guillaume Sescousse1,2,3, Jérôme Brunelin1,2,3
1PSYR, CNRL, INSERM U1028, CNRS UMR5292, UCBL1, Bron, France.
EClinicalMedicine
|September 21, 2023
概括
在精神分裂症谱系障碍中使用大麻与增加的积极和兴奋症状有关,但减少了负面症状. 需要进一步的研究来理解这些复杂的关联.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 成 药物 药物 药物 药物
背景情况:
- 大麻使用与精神分裂症谱系障碍的积极症状之间的关联得到了充分证实,但关于负面症状的发现是不一致的.
- 之前的元分析使用了聚合数据,可能通过忽视混变量引入偏差.
- 像混乱,抑郁和兴奋这样的维度在这个人群中与大麻使用有关的研究不足.
研究的目的:
- 利用个人参与者数据元分析 (IPDMA) 调查大麻使用与精神分裂症谱系障碍中的各种症状维度之间的关联.
- 通过结合混变量来解决以前聚合数据元分析的局限性.
- 检查大麻使用对正面,负面,混乱,抑郁和兴奋症状维度的影响.
主要方法:
- 进行了个人参与者数据元分析 (IPDMA),搜索了PubMed,ScienceDirect和PsycINFO.
- 分析了来自21项研究的数据,共有3677名患有精神分裂症谱系障碍的参与者.
- 纳入标准涉及诊断的大麻使用障碍或每周至少两次使用大麻,心理病理由正负综合征量表 (PANSS) 评估.
主要成果:
- 大麻使用与积极症状 (aMD = 0.38,95% CI [0.08; 0.63]) 和兴奋症状 (aMD = 0.16,95% CI [0.03; 0.28)) 的更高严重程度有关.
- 在大麻使用者中观察到负面症状的严重程度较低 (aMD = -0.50,95% CI [-0.91; -0.08]).
- 在大麻使用和混乱或抑郁症状之间没有发现显著的关联.
结论:
- 大麻使用可能对精神分裂症谱系障碍的症状维度产生差异性影响,可能会加剧积极和兴奋症状,同时缓解负面症状.
- 观察到的效应大小很小,并且由于信任区间很宽,应谨慎地解释研究结果.
- 建议进行纵向研究,以阐明因果关系和大麻在这些关联中的确切作用.
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