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关于阿尔茨海默氏症中突触可塑性的全球趋势和前景:一本书法分析分析
Yingying Zhang1, Junyao Zhang1, Yinuo Wang1
1Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
突触可塑性在阿尔茨海默病 (AD) 发病过程中至关重要. 研究趋势显示,神经炎症,微质细胞和α-synuclein作为潜在AD治疗重点领域的关键领域的转变.
科学领域:
- 神经科学是一个神经科学.
- 病理学 病理学 病理学
- 图书统计学 图书统计学
背景情况:
- 突触可塑性障碍是阿尔茨海默病 (AD) 的关键致病因素和早期特征.
- 了解AD中突触可塑性的研究格局对于推进该领域至关重要.
研究的目的:
- 系统地分析和理解有关阿尔茨海默氏症突触可塑性的研究趋势和热点,使用文献识别分析.
- 确定主要的国家,机构,作者和期刊为这一研究领域做出贡献.
主要方法:
- 从Web of Science核心集合 (2002-2022) 中对2,348篇出版物的图书法分析.
- 利用CiteSpace,VOSviewer和在线图书统计平台进行数据分析.
- 关键词爆发检测被用来识别新兴的研究主题.
主要成果:
- 突触可塑性和AD研究的出版物和引用数量在过去二十年里稳步增加.
- 美国在出版物方面处于领先地位,美国和中国之间经常有合作.
- 哈佛大学和DJ Selkoe在出版物和引文中占据着重要地位;阿尔茨海默病杂志是主要的出版场所.
- 研究重点已经从突触传播和斑块形成演变为神经炎症,微质细胞和α同核素.
结论:
- 图书统计分析揭示了阿尔茨海默病突触可塑性研究的显著增长和发展趋势.
- 目前的研究热点,包括神经炎症,微质和α同核素,表明在AD管理中临床应用的有希望途径.
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