刺激性肠综合征中的早期不利暴露:新的见解和机会
Guo Qiong Zhou1, Meng Jie Huang1, Xin Yu1
1Department of General Practice, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.
Frontiers in pediatrics
|September 21, 2023
概括
不良的早期生命暴露,包括饮食,抗生素,压力,食和分娩方式,显著增加患上易怒肠综合征 (IBS) 的风险. 这些因素会破坏肠道微生物群和大脑-肠轴,为IBS创造一个易受感染的窗口.
科学领域:
- 胃肠病学 胃肠病学
- 发展生物学 发展生物学
- 免疫学 免疫学 免疫学
背景情况:
- 刺激性肠综合征 (IBS) 是一种常见的功能性胃肠疾病,其原因有多种因素.
- 生命早期的暴露越来越被认为是IBS易感性的关键决定因素.
- 饮食,抗生素,压力,食习惯和分娩方式显著影响正在发展的肠道和脑肠轴.
研究的目的:
- 综合审查证据,将不良早期暴露与IBS发展联系起来.
- 阐明这些暴露影响IBS病变的机制.
- 确定新的研究方向,以了解和预防与早期生活相关的IBS.
主要方法:
- 对现有关于早期生活因素和IBS的文献进行系统审查.
- 分析调查饮食,抗生素,压力,食和分娩方式对肠道微生物群,免疫系统和脑肠轴的影响的研究.
- 综合从怀孕,产后和新生儿时期的证据.
主要成果:
- 生命早期的饮食变化改变了微生物群的组成,肠道结构,基因表达和脑肠轴的功能.
- 在怀孕期间和新生儿时使用抗生素会破坏肠道微生物群,反映IBS患者的个人资料.
- 早期的生活压力,配方养和某些分娩方式会对免疫平衡,肠道屏障完整性和微生物殖民产生负面影响,增加IBS风险.
结论:
- 早期的不良生命暴露是IBS发展的关键窗口.
- 机制包括失生症,免疫失调,肠道屏障受损以及脑肠轴信号的改变.
- 对这些早期生活因素的进一步研究对于从童年到成年期开发有效的IBS预防和治疗策略至关重要.
相关概念视频
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Altered...
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Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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