莫达菲尼尔对双相情感障碍情感稳定患者的认知和睡眠质量的影响:试点研究
Jessica M Lipschitz1,2, Mercedes Perez-Rodriguez3, Marzieh Majd1,2
1Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, United States.
Frontiers in psychiatry
|September 21, 2023
概括
莫达菲尼尔可以改善认知和减少双相情感障碍 (BD) 患者的白天嗜睡,但可能会恶化睡眠质量. 对这种患者群体需要进一步的研究.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 双极性障碍 (BD) 的治疗往往无法实现完全康复,使患者保持持续的功能障碍.
- 神经认知缺陷,白天活动减少和睡眠障碍在BD患者的缓解期间也很常见.
研究的目的:
- 评估modafinil在改善神经认知功能,白天嗜睡和情感稳定的BD患者的睡眠质量的可行性,安全性和初步疗效.
主要方法:
- 一个为期8周的随机,安慰剂控制的试点研究.
- 12名情绪稳定的BD患者接受了灵活剂量的modafinil (100-200 mg/天) 或安慰剂,以及情绪稳定剂.
- 评估包括每周监测睡眠,嗜睡,副作用和情绪,在基线,第4周和第8周进行神经认知测试.
主要成果:
- 莫达菲尼尔相对安全,副作用包括心,,疲劳和能量下降.
- 与安慰剂相比,在modafinil组中观察到处理速度和口头学习的边际显著改善.
- 莫达菲尼尔组显示白天嗜睡减少,但与安慰剂组相比,睡眠质量较差.
结论:
- 莫达菲尼尔在情感稳定的BD患者的辅助治疗中似乎是安全的,可能提供认知和白天嗜睡的好处.
- 服用莫达菲尼尔的患者的睡眠质量下降,需要进一步调查.
- 建议进行更大规模的临床试验,以确定最有可能从modafinil中受益的患者子组.
更多相关视频
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
5.4K
04:34Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
1.1K
相关概念视频
01:19Management of Insomnia
274
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
274
01:24Mania and Antimanic Drugs: Overview
215
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
215
01:24Substance Use Disorders Affecting Sleep
188
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
188
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
196
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
196
01:23Antidepressant Drugs: MAOIs and Other Agents
266
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
266
01:30Bipolar Disorder
78
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
78