解剖学建模和光斑对比光学断层扫描的优化 光学断层扫描
Chen-Hao P Lin1,2, Inema Orukari2, Lisa Kobayashi Frisk3
1Department of Physics, Washington University in St. Louis, St. Louis, MO, 63130, USA.
bioRxiv : the preprint server for biology
|September 21, 2023
概括
斑点对比光学断层扫描 (SCOT) 现在可以使用基于MRI的模型绘制人类大脑血流 (CBF) 的地图. 这一进步提高了成像分辨率和信号噪声比,为临床应用铺平了道路.
科学领域:
- 生物医学光学 生物医学光学
- 医疗成像医学成像
- 神经科学是一个神经科学.
背景情况:
- 传统的脑血流 (CBF) 测绘方法 (PET,MRI) 由于后勤限制,提供有限的时间数据.
- 斑点对比光学断层扫描 (SCOT) 对CBF映射有希望,但由于缺少解剖重建和设计参数不确定性,缺乏人类应用.
结论:
- 开发的建模方法使基于解剖学的SCOT图像重建能够用于人类CBF映射.
- 这些方法对于评估各种组织状况,测量参数和噪声源非常有价值.
- 告知了SCOT系统的设计,并证明了其临床转化潜力.
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