年代型与老年人睡眠质量有关
Scott C Sauers1, Cristina D Toedebusch1, Rachel Richardson1
1Department of Neurology, Washington University School of Medicine, St Louis, MO 63110.
medRxiv : the preprint server for health sciences
|September 21, 2023
概括
老年人晚期时刻型与睡眠质量差和大脑活动改变有关. 了解睡眠时间可能有助于识别阿尔茨海默病风险并追踪干预的有效性.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 老年学是一门学科.
背景情况:
- 睡眠障碍在阿尔茨海默病 (AD) 中很普遍,可能表明AD风险.
- 时型或睡眠时间影响睡眠-清醒周期,与阿尔茨海默病有关,但其与老年人睡眠模式的关系尚不清楚.
研究的目的:
- 研究老年人的各种睡眠测量和时间型之间的关联.
- 为了确定这些关联是否在考虑到与阿尔茨海默病相关的混因素之后仍然存在.
主要方法:
- 243名老年人 (平均年龄74岁) 接受了认知评估,脑脊液 (CSF) 阿尔茨海默病生物标志物测量和睡眠监测.
- 睡眠监测包括单通道脑电图 (EEG),动图和自我报告的睡眠日志.
- 时刻型被定义为睡眠的中点,用动图法测量.
主要成果:
- 晚期的睡眠中点 (晚期的年代型) 与非洲裔美国人种族和更大的睡眠中点变化有关.
- 在控制了年龄,种族,性别,认知状况,AD生物标志物和睡眠障碍后,晚期时刻型与较长的快速眼动 (REM) 睡眠开始延迟,减少REM睡眠持续时间,睡眠效率降低,睡眠开始延迟增加和更多的夜间觉醒相关.
- 晚期时代型也与非快速眼动 (非REM) 慢波活动 (<2 Hz) 的增加有关.
结论:
- 睡眠,特别是时间型,可以作为一种非侵入性生物标志物,用于跟踪个体的认知障碍风险和干预反应.
- 时间型是阿尔茨海默病的潜在可修改的风险因素,在使用睡眠作为阿尔茨海默病风险标志物时应考虑.
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